Avaliação funcional e articular em uma coorte prospectiva de portadores de hemofilia no Distrito Federal

Abstract

Introduction: Arthropathy is the most frequent musculoskeletal disease in patients with hemophilia. It is described by pain, loss of range of motion, deformities and weakness of muscles adjacent to that affected joint. Through the periodic assessment of joint status, there is a better understanding of the functional condition of these patients. Thus, there is a more efficient and global treatment. Purpose: To evaluate the functional and joint performance, as well as the frequency of the use of the coagulation factor by hemophilic patients registered in the Federal District after one-year follow-up. Method: This is a prospective cohort study with 69 severe hemophilia patients followed from 2014 to 2018 at Fundação Hemocentro de Brasília, DF. The patients were assessed according to the HJHS and FISH scores at one-year intervals and correlated with others. Variables such as age, coagulation factor replacement method and treatment adherence were collected. For data analysis we used the Kolmogorov-Smirnov test, Student's t test, Wilcoxon test, McNemar test, Mann-Whitney test, and Pearson's chi-square test (χ2). The association between quantitative variables was performed by Pearson correlation or Spearman correlation, as appropriate. Results: The correlation between age and HJHS was significant (p = 0.0049). The correlation between adherence and HJHS was significant (p = 0.01). The correlation between adherence and FISH was significant for delta (p <0.05). The correlation between prophylactic treatment and HJHS was statistically significant (p = 0.004), as well as with FISH (p = 0.03).Conclusion: The older the patient, the greater the likelihood of worsening in the HJHS score; The higher the age, when more arthropathies are installed, the FISH score is worse and patients who use primary prophylaxis have better HJHS and FISH scores compared to patients on secondary prophylaxis and/or under demand use.